Bueter 5/8
نویسندگان
چکیده
Self-tolerance and tumor-induced peripheral tolerance may be responsible for the limitations of the immune system in controlling tumor growth in cancer patients. It is known, that self-proteins are continuously processed and presented by antigen presenting cells. During development, auto-reactive T cells encountering self peptide/self-MHC complexes are being eliminated in the thymus. This process called ‘negative selection’ results in the removal of nascent auto-reactive T cells thus preventing an autoimmune attack of our own tissues. Many self-peptides (e.g. parts of p53), despite their high affinity for self-MHC, remain cryptic in the thymus and do not mediate cell deletion. Under conditions that favor up-regulation of cryptic self-determinants, one or more of these subsets of the ‘protected’ T cell repertoires, can be stimulated by these self-determinants, leading to induction of autoreactivity. The latter could eventually result in autoimmunity under permissive conditions governed by MHC and non-MHC genes. Thus, considering tumor tissue a ‘modified self-tissue’, this process that may have evolved to prevent excessive purge of the T cell repertoire, providing the potential for the development of autoimmune responses and therefore for anti-cancer therapy in adults.
منابع مشابه
Author's response to reviews Title: Evaluation of Immunological Escape Mechanisms in a Mouse Model of Colorectal Liver Metastases Authors:
Martin Grimm ([email protected]) Martin Gasser ([email protected]) Marco Bueter ([email protected]) Johanna Strehl ([email protected]) Johann Wang ([email protected]) Ekaterina Nichiporuk ([email protected]) Detlef Meyer ([email protected]) Christoph T Germer ([email protected])...
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